International Symposium on Telecommunication (IST)

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Simulation of Cell Movement Control by Magnetophoretic Chips

Authors :

Mohammadreza Yousefi¹ Mohammad Taheri²

1- دانشگاه آزاد اسلامی واحد نجف آباد 2- دانشگاه آزاد اسلامی واحد نجف آباد

Keywords :

magnetic transport،microfluidics،MEMS،lab on a chip،magnetic manipulation

Abstract :

Abstract— Magnetic nanoparticles have attracted a lot of attention in various fields, including engineering and medicine. Magnetophoretic and microfluidic chips are suitable tools in lab-on-a-chip systems for locating, precisely controlling particle movement, combining, manipulating and examining magnetic particles and cells with magnetic labels. Recently, inspired by electronic circuits for the controlled transfer of particles on a chip in a magnetic field, magnetic circuits have been introduced in which a capacitor-like model is used to store cells and a diode-like model is used to store cells. Transistor cell transfer method is also used for switching (transfer of the selected cell). Thus, single-cell analysis is an emerging field that has had a transformative impact on cell biology over the past decade. Progress in this field requires systems that are capable of precise movement of cells and magnetic particles in a controlled manner. In this research, in order to obtain a multiple array for the addressable transfer of cells with magnetic label, in order to investigate the cell transfer in 90, 270 degrees bends in the TI transfer path with disk pattern and I strip, simulation has been done. A multiple array is then designed. The pattern of the injection site in the TI tracks is also designed to avoid the initial deviation of the cell on the magnetophoretic chips to reach the intended main track.

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